Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background.
Rattachement africain : us, hu. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Murine ulcerative dermatitis (UD) is a common progressive condition of mice with a C57BL/6 background. Typically, mice present with scabs and crusts on the skin of the dorsal neck and ears, and are often severely pruritic. Animals tend to scratch the lesions, causing additional trauma to the already ulcerated and inflamed skin. Therapeutic intervention largely has been unsuccessful, in part due to the lack of a known cause for the disease. Though the exact etiology of UD has not been elucidated, substance P (SP) has recently been demonstrated as an important neuropeptide linked to the itch-scratch cycle. SP functions at the tachykinin neurokinin 1 (NK1) receptor. We hypothesized that inhibition of SP binding to the NK1 receptor would decrease the itch sensation, thus decreasing scratching behavior and subsequent skin trauma. The purpose of this study was to evaluate the effectiveness of an NK1 receptor antagonist, maropitant citrate, as a treatment for murine UD. Treatment with 1 mg/kg maropitant citrate significantly reduced the size of UD lesions in mice.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
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Yale University pays non établi dans la noticeUniversité ou école supérieure
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University of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Section of Comparative Medicine pays non établi dans la noticeUniversité ou école supérieure
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Comparative Medicine (Veterinary Medicine) pays non établi dans la noticeInstitution
Yale University, University of Veterinary Medicine et Section of Comparative Medicine — School of Medicine, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.