Chongqing Institute for Brain and Intelligence

Neurovascular Unit Dysfunction in Ischemic Stroke: Cellular and Molecular Mechanisms and Therapeutic Implications

Yonglong Zhang, Minjie Luo, Zuzhen Wang, Ziqin Wang et autres

Ischemic stroke represents a complex and devastating neurological disorder characterized by acute cerebral blood flow reduction, extensive neuronal injury, and multifaceted vascular and inflammatory alterations. The pathophysiology of ischemic stroke extends far beyond neuronal damage and critically involves dysfunction of the neurovascular …

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Wide-Field Ca2+ Imaging Reveals Cortical Dynamics Across Propofol Anesthesia and Emergence in Adult Mice

Ziyi Zhang, Lin Ai, Xi Zheng, Jun Zhang et autres

BACKGROUND: Precise control of propofol anesthesia depth is critical for perioperative safety; however, the dynamic reorganization of large-scale cortical functional networks throughout propofol anesthesia and recovery remains incompletely understood. This study employs wide-field imaging to record neuronal activity and functional connectivity across …

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Quantification of microglial dynamic motility in vivo

Ran Ran, Dong Wang, Jin Zhao, Linlin Hu et autres

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Efficacy and safety of sublingual cilostazol and dexborneol for the treatment of acute ischaemic stroke: a randomised phase 2 trial in China

Yicong Wang, Yi Sui, Hui Qu, Yuesong Pan et autres

Background: Endovascular treatment has emerged as a cornerstone intervention for acute ischaemic stroke caused by large-vessel occlusion. However, a subset of patients experience futile recanalisation, correlating with unfavourable long-term outcomes. We aimed to investigate the efficacy and safety of Y-6 sublingual tablets …

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Author response: Brainstem neurons coordinate the bladder and urethral sphincter for urination

Xing Li, Xianping Li, Jun Li, Han Qin et autres

Estrogen receptor 1 (ESR1)-positive neurons in the pontine micturition center govern detrusor–sphincter coordination via three distinct spinal projections, representing a therapeutic target for detrusor–sphincter dyssynergia and associated voiding dysfunction.

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Early and prolonged oral edaravone for neuroprotection in acute ischemic stroke: the ERASE-STROKE randomized controlled phase 3 trial

Yang Xiang, Weilin Jin, Xin-Chen Zhu, Yan Song et autres

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Comparative analysis of SCGN expression patterns in the anterior pituitary gland of mouse, pig, and human by single‐cell transcriptomics

Cheng‐Cheng Wang, Qilin Zhang, Zhenle Zang, Huachun Yin et autres

Secretagogin (SCGN) is a calcium-binding protein implicated in neuroendocrine secretion. However, its expression profile in the anterior pituitary gland and potential species-specific differences remain poorly characterized. We analyzed scRNA-seq data from the pituitary glands of mice, rats, pigs, and humans, then combined …

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Layer 1 NDNF interneurons modulate thalamocortical input to the auditory cortex

Jie Tao, Yuehua Chen, Mahiber Polat, Sunny C. Li et autres

Neural microcircuits in the auditory cortex (AuC) are essential for auditory information processing. Recent studies identified the basal region of the ventromedial nucleus of the thalamus (bVM), which affects AuC neuronal responsiveness and contributes to sound discrimination. However, the microcircuit organization by …

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Data from: Brainstem neurons coordinate the bladder and urethral sphincter for urination

Li X, Jun（Mr） Li, Han Qin, Shanshan Liang et autres

This dataset contains the source data supporting our findings that estrogen receptor 1 (ESR1)-positive neurons in the pontine micturition center govern detrusor-sphincter coordination via three distinct spinal projections. It includes fiber photometry, single-unit optrode recordings, optogenetics, simultaneous cystometry and electromyography (EMG), anatomical …

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Mesencephalic astrocyte-derived neurotrophic factor suppresses ferroptosis to alleviate depressive-like behaviors via the PERK/ATF4 signaling pathway

Ruozhi Dang, Peng Wang, Wenhua Li, Mingyang Wang et autres

Ferroptosis is being increasingly implicated in the pathophysiology of major depressive disorder (MDD). Endoplasmic reticulum (ER) stress is closely linked to ferroptosis, yet the endogenous regulators connecting ER dysfunction to ferroptosis during chronic stress remain unclear. Here, we report that the expression …

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Cognitive Strategy-based neuromodulation optimizes neural communication to improve working memory

Yin Tian, Congming Tan, Yuhao Jiang, Peiyang Li et autres

Rapid and effective enhancement of memory function through the integration of neuromodulation and cognitive training has been a longstanding objective in cognitive science and translational medicine. Research indicates that efficient training strategies are associated with rapid improvements in working memory (WM) performance, …

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Simultaneous Recordings of Neuronal Activities, Pup Calls, and Maternal Behaviors in Lactating Mice

Yueling Zang, Jiechang Tang, Xia Wang, Shanshan Liang et autres

Maternal behaviors are crucial for the survival and well-being of mammalian offspring. While previous studies have implicated both subcortical and cortical areas, including the auditory cortex (AuCx), in the regulation of maternal behaviors, the real-time dynamics of AuCx neuronal activity in response …

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