Hannover Clinical Trial Center (Germany)

Canakinumab or emavusertib for anemia in lower-risk MDS: results of the CANFIRE and LUCAS phase 2, open-label, multicenter trials

Anne Sophie Kubasch, Katharina Zoldan, Dominic Brauer, Philipp Kiewe et autres

BACKGROUND: Dysregulated innate immune signaling promotes inflammatory suppression of hematopoietic stem and progenitor cell function, contributing to ineffective erythropoiesis in myelodysplastic neoplasms (MDS). The phase 2, open-label CANFIRE and LUCAS trials aimed to determine the efficacy and safety of canakinumab or emavusertib, …

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FuturePall: Forecasting the specialized inpatient palliative care in Germany based on demographic trends and utilization rates.

M A Kamp, J Bergmann, C von Saß, L Fink et autres

de (code pays fourni par la source)

Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor

Marcus Renner, Małgorzata Oleś, Nagarajan Paramasivam, Christoph E. Heilig et autres

Desmoplastic small round cell tumor (DSRCT) is an ultra-rare sarcoma with limited treatment options. Here, we show that comprehensive molecular profiling informs diagnosis and individualized therapy in this disease. We report the results of whole-genome/exome, transcriptome, and DNA methylome analyses performed in …

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Safety, tolerability and early efficacy of mdc-CAR-BCMA001 – a high affinity BCMA targeting CAR T-cell therapy in patients with multiple myeloma and diffuse large B-cell lymphoma

Abstract Background: BCMA is a validated target for T-cell engagers and chimeric antigen receptor (CAR) T-cell therapy in multiple myeloma (MM). Initial response rates of BCMA directed therapies are high but relapse remains a significant problem. Some early reports also suggest low …

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Delay of Systemic Therapy Confers a Survival Benefit in Patients with Stage IV Non-Small-Cell Lung Cancer

Rike Geiken-Weinstock, Frank Griesinger, Michael Patrick Metz, Ralf Georg Meyer et autres

Background: A timely systemic therapy of patients with metastasized non-small-cell lung cancer (NSCLC) is a suggestive clinical conception. As the pre-therapeutic management is complex and includes comprehensive immunohistochemical and molecular diagnostics, the time to optimal therapy may be prolonged. Whether the timing …

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Einfluss der Krankenhausstrukturreform und sozio-ökonomischer Deprivation in NRW auf die Erreichbarkeit spezialisierter stationärer Palliativversorgung

Christiane von Saß, Ulrich Wedding, Joachim Bergmann, Larissa Fink et autres

Palliative care aims to improve the quality of life for patients with potentially life-threatening illnesses and their families by early identification and treatment of physical, psychosocial, and spiritual suffering and symptoms. The aim of this study was to examine the impact of …

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Geographical accessibility and case loads in subarachnoid hemorrhage care: a nationwide study of German hospitals

Nazife Dinc, Christiane von Saß, Sergio A. Calero-Martinez, Sae‐Yeon Won et autres

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Oral Ferric Maltol Improves Iron Deficiency Anaemia in Patients with Chronic Heart Failure

Tibor Kempf, Welf Geller, Jan Fuge, Mircea‐Andrei Sandu et autres

de (code pays fourni par la source)

Leveraging machine-learning techniques to detect recurrences in cancer registry data: A multi-registry validation study using German lung cancer data

Henrik Kusche, Christopher Gundler, Ole Johanns, Markus Sauerberg et autres

BACKGROUND: Cancer recurrence and progression, once seen as markers of poor prognosis, are now considered manageable aspects of long-term care. Advances in treatment have extended survival, emphasizing the need for representative epidemiological information. Population-based cancer registries are essential in this respect. However, …

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MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans

Leonie Mayer, Leonie Marie Weskamm, Anahita Fathi, Maya Kono et autres

In response to the COVID-19 pandemic, multiple vaccines were developed using platforms such as viral vectors and mRNA technology. Here, we report humoral and cellular immunogenicity data from human phase 1 clinical trials investigating two recombinant Modified Vaccinia virus Ankara vaccine candidates, …

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Correction to: Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site

Maud Kamal, Sonia Lameiras, Marc Deloger, Adeline Morel et autres

The original version of this article contained an error in an affiliation. Upon careful review of the paper, the authors noticed that the affiliation for Goran Malenkovic was not written correctly. The authors only submitted the following affiliation Gynecologic Oncology Department Clinic …

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Effect of Spironolactone Wash-Out on Albuminuria After Long-Term Treatment: The AFTER-PRIORITY Study

Victor Soendergaard Wasehuus, Viktor Rotbain Curovic, Nete Tofte, Morten Kofod Lindhardt et autres

Background: The PRIORITY study showed that treatment with spironolactone did not prevent progression to microalbuminuria in high kidney risk individuals as classified by the urinary proteomic risk classifier - CKD273. As spironolactone has previously shown to significantly lower albuminuria levels in chronic …

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