Japan BCG Laboratory

Mucosal BCG Vaccination and Immune Layering: Route-Dependent Programming of Immunity at the Respiratory Interface

Yukihiro Shibuya, Miyu Sakai, Hideyasu Kiyohara

Mycobacterium bovis Bacille Calmette–Guérin (BCG), the only licensed vaccine against tuberculosis, provides inconsistent protection against pulmonary tuberculosis, reflecting an incomplete understanding of how vaccine-induced immunity is organized within tissues. Emerging evidence indicates that the route of vaccination is not merely a technical …

jp (code pays fourni par la source)

A Case Study on Bug Seeding in a University Course on Software Development and Testing

Satoshi Masuda, Tohru Matsuodani

jp (code pays fourni par la source)

Multimodal EEG-fNIRS Fusion for Passive BCI-based Depressive State Classification

Riki Sakurai, Simon Kojima, Mihoko Otake-Matsuura, Shin’ichiro Kanoh et autres

Abstract Traditional psychiatric assessments for depression are often hindered by subjective bias and patient recall in-accuracy. This paper presents a multimodal passive Brain-Computer Interface (pBCI) designed for the objective screening of depressive traits through the end-to-end decoding of neural dynamics. We implemented …

jp, fr, pl (code pays fourni par la source)

Development of a multi-targeted metabolomics platform for semi-quantification of faecal metabolites: a proof-of-concept analysis in human faeces

Kayo Ikuta, Akihiro Kunisawa, Itaru Dekio, Arisa Ito et autres

Objectives: Targeted metabolomic analysis of faecal samples has been limited by narrow chemical coverage. Here, we established a multiplexed, triple quadrupole mass spectrometry (TQMS)-based targeted metabolomics workflow. This workflow allows accurate detection and semi-quantification of diverse faecal metabolites and provides a methodological …

jp, gb (code pays fourni par la source)

An Inductive–Inductive–Capacitive Hybrid In-Cell Touch Sensor for Bottom-Emission OLED Displays

Seong-Ro Lee, Myeong-Cheol Hyun, Jae-Ha Lee, Jae-Sung An et autres

kr, jp (code pays fourni par la source)

Correction: Accurate deep-learning model to differentiate dementia severity and diagnosis using a portable electroencephalography device

Masahiro Hata, Takufumi Yanagisawa, Yuki Miyazaki, Hisaki Omori et autres

The original version of this Article contains errors Table 1 and Table 2, where the number of healthy volunteers (HVs) was incorrectly stated as 121. As a result, the values in the “HV” row in the “Gender male/female” column, in the “ …

jp (code pays fourni par la source)

Development of a Novel Mucosal Vaccine Vector Derived From Human Parainfluenza Virus Type 2 and Its Efficacy as a SARS‐CoV‐2 Vaccine by Intratracheal Administration Using Transgenic Mice Expressing Human Angiotensin‐Converting Enzyme 2

Akira Kawano, Masamitsu N. Asaka, Mitsuo Kawano, Hidehisa Sekijima et autres

We created a novel replication-incompetent vector derived from the human parainfluenza virus type 2 (hPIV2). The vector lacks the hemagglutinin-neuraminidase (HN) gene (hPIV2/∆HN) that is essential for virus attachment and release. We also generated the stable packaging cell line expressing hPIV2 HN …

jp (code pays fourni par la source)

A case of infective endocarditis following urinary tract infection by Proteus mirabilis

Kohei Maruyama, Naoya Harada, Hiroki Katsumata, Minato Kawaguchi et autres

us, jp (code pays fourni par la source)

Accurate deep-learning model to differentiate dementia severity and diagnosis using a portable electroencephalography device

Masahiro Hata, Takufumi Yanagisawa, Yuki Miyazaki, Hisaki Omori et autres

Mild cognitive impairment (MCI) and dementia pose significant health challenges in aging societies, emphasizing the need for accessible, cost-effective, and noninvasive diagnostic tools. Electroencephalography (EEG) is a promising biomarker, but traditional systems are limited by size, cost, and the need for skilled …

jp (code pays fourni par la source)

Culture filtrate proteins from Bacillus Calmette–Guérin

Yukihiro Shibuya

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) has long been used as a vaccine against tuberculosis and bladder cancer. BCG is also an effective adjuvant; it has long been known that its cell wall acts as an adjuvant. Recent research has revealed that various …

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Experimental and Theoretical Approaches for Detecting Latent Lateral Leakage Current of Organic Light-Emitting Diodes

Kazunori Morimoto, Ryu-ichi Satoh, Seonghee Noh, Takayuki Miyamae

High-resolution organic light-emitting diode (OLED) displays often suffer from image quality deterioration due to lateral leakage current (LLC). We performed the detection of LLC using operando electric-field-induced doubly resonant sum-frequency generation (EFI-DR-SFG) measurements under conditions where the electric potential, formed by the …

jp (code pays fourni par la source)

Preparation, solubility, and anti-inflammatory effects of a complex of diphenylcyclopropenone/β-cyclodextrin derivatives as the treatment of alopecia areata

Yutaka Inoue, Kaede Yoshino, Suzu Kudo, Nao Kodama et autres

Purpose: To investigate the preparation of inclusion complexes of diphenylcyclopropenone (DPCP)/β-cyclodextrin (β-CD) derivatives using a three-dimensional (3D) ball mill, and verify the inclusion behavior of the solid dispersion. Additionally, we aimed to investigate the effect of DPCP/β-CDs complex formation on the spleens …

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