Cabinet Gastroenterology La Source-Beaulieu

P1162 Upadacitinib in Crohn’s Disease Patients: for what type of patients in real world setting ?

Pascal Juillerat, Maude Martinho-Grueber, Roseline Ruetsch, Hayssam Moubayed et autres

Abstract Background The oral selective JAK kinase inhibitor, Upadacitinib (UPA; Rinvoq®) has been shown to induce and maintain clinical response and remission in Crohn’s disease (CD), but also in rheumatic and skin diseases. We report here on the largest Swiss experience in …

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Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Goncalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis et autres

Since the publication of this work, Eli M Carrami has changed their name from Mohammad Karaminejadranjbar. This has now been amended in the HTML and PDF versions of the article.

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Potential to Improve Therapy of Chronic Myeloid Leukemia (CML), Especially for Patients with Older Age: Incidence, Mortality, and Survival Rates of Patients with CML in Switzerland from 1995 to 2017

Michael Daskalakis, Anita Feller, Jasmine Noetzli, Nicolas Bonadies et autres

BACKGROUND: Tyrosine kinase inhibitors (TKI) substantially improved chronic myeloid leukemia (CML) prognosis. We aimed to describe time period- and age-dependent outcomes by reporting real-world data of CML patients from Switzerland. METHODS: Population-based incidence, mortality, and survival were assessed for four different study …

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Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

Philipp Wuggenig, Berna Kaya, Hassan Bachir Melhem, C. Korcan Ayata et autres

Abstract Comprehensive development is critical for gut macrophages being essential for the intestinal immune system. However, the underlying mechanisms of macrophage development in the colon remain elusive. To investigate the function of branched-chain amino acids in the development of gut macrophages, an …

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Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Goncalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis et autres

Abstract Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients (median age-at-diagnosis of 3.5 years), in whom no Mendelian disorders were clinically suspected. In …

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P657 Evolution of Crohn’s disease progression and surgery rates over 10 years for patients who initiated biologic treatment early compared with late or no biologic initiation

Nadia Pillai, Mark Dusheiko, Michel H. Maillard, Pierre Michetti et autres

Abstract Background This study aimed to evaluate the clinical outcomes for adults diagnosed with Crohn’s disease (CD) who started biologic treatments within 2 years of diagnosis (early initiation) compared with those who started biologics >2 years after diagnosis or who did not …

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Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Bahtiyar Yılmaz, Pascal Juillerat, Ove Øyås, Charlotte Ramon et autres

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Microbial network disturbances in relapsing refractory Crohn’s disease

Bahtiyar Yılmaz, Pascal Juillerat, Ove Øyås, Charlotte Ramon et autres

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Vedolizumab in Refractory Microscopic Colitis: An International Case Series

Pauline Rivière, Andreas Münch, Pierre Michetti, Nilesh Chande et autres

BACKGROUND: Evidence for second-line therapy in patients with microscopic colitis [MC] failing budesonide is scarce, although anti-tumour necrosis factors [anti-TNFs], methotrexate and azathioprine have been reported to be effective in small cohort studies. Vedolizumab, a monoclonal antibody targeting α4β7-integrin, prevents homing of …

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Efficacy of infliximab biosimilars in patients with Crohn's disease

Pierre Michetti

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Structural Basis of Bone Fragility in Young Subjects with Inflammatory Bowel Disease

Jessica Pepe, Sophie Zawadynski, François Richard Herrmann, Pascal Juillerat et autres

BACKGROUND: The onset of inflammatory bowel disease (IBD) during childhood/adolescence compromises peak bone mass acquisition and predisposes to fractures later in life. However, the structural basis for bone fragility in young adults with IBD remains unknown. METHODS: One hundred two young subjects …

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Calprotectin in Daily Practice: Where Do We Stand in 2017?

Fabrizia D’Angelo, Christian P. Felley, Jean‐Louis Frossard

BACKGROUND: To make a distinction between organic and functional disease is essential for gastroenterologists in their daily practice, but it may be challenging, given the variety and aspecificity of gastrointestinal symptoms among the general population. The clinician aim is to avoid diagnostic …

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