Abstract B044: Targeting the “undruggable” oncogene CCNE1 using a molecular glue degrader in CCNE1 amplified cancers
William Tahaney, Yimao Liu, Ahmed Abdullah, Vittoria Massafra et autres
0 citationsClinical Cancer Research
Jnana Therapeutics (United States)
Boston · US · company
63Publications signalées
8580Citations signalées
12Thèmes principaux
Principaux domaines
Click Chemistry and ApplicationsProtein Degradation and InhibitorsAmino Acid Enzymes and MetabolismCancer-related Molecular PathwaysChemical Synthesis and AnalysisMetabolism and Genetic DisordersUbiquitin and proteasome pathwaysRNA modifications and cancerPharmaceutical studies and practicesPharmacogenetics and Drug MetabolismCancer, Hypoxia, and MetabolismCRISPR and Genetic Engineering
Évolution annuelle
Publications récentes
Abstract PR003: Targeting the “undruggable” oncogene CCNE1 using a molecular glue degrader in CCNE1 amplified cancers
William Tahaney, Yimao Liu, Ahmed Abdullah, Vittoria Massafra et autres
0 citationsClinical Cancer Research
Abstract 4015 RAPID – Photoaffinity-based High-throughput Ligand Discovery in Cells
Justin Rettenmaier, Matthew Labenski, Dean Brown, Andreu Viader et autres
0 citationsJournal of Biological Chemistry
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
Stefano Annunziato, Chao Quan, Etienne J. Donckèle, Ilaria Lamberto et autres
6 citationsNature Structural & Molecular Biology
A mouse model of a patient derived P544L mutation in the Slc6a8 gene shows hypoactivity and cognitive deficits
Marla K. Perna, Lara Gechijian, Heather Blanchette, Rosalyn Liou et autres
0 citationsBrain Research
What Do Oral Drugs Really Look Like? Dose Regimen, Pharmacokinetics, and Safety of Recently Approved Small-Molecule Oral Drugs
10 citationsJournal of Medicinal Chemistry
Abstract 4366666: Selective Degradation of NIMA-related kinase 7 (NEK7) via a Molecular Glue Degrader Inhibits IL-1 Downstream of NLRP3 Inflammasome Activation: A Novel Therapeutic Approach for Cardiovascular Inflammation
Daric Wible, Coleman Komishane, Vanessa K. Verdine, Qian Chen et autres
1 citationCirculation
Rat superficial masseter operates at long lengths during biting
Nicolai Konow, Brandon Reder, Daniel T. Bartlett, Devin Jenness et autres
3 citationsScientific Reports
TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11 -Mutant Tumors to Anti–PD-1 Immunotherapy
Leanne G. Ahronian, Soumyadip Sahu, Minjie Zhang, Ayushi S. Patel et autres
6 citationsCancer Research
Dual-vector rAAVrh8 gene therapy for GM2 gangliosidosis: a phase 1/2 trial
Florian Eichler, Oğuz Çataltepe, Rrita Daci, Ajit S Puri et autres
8 citationsNature Medicine
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
Georg Petzold, Pablo Gaínza, Stefano Annunziato, Ilaria Lamberto et autres
90 citationsScience
Current and Emerging Prodrug Strategies
24 citationsJournal of Medicinal Chemistry
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