Hospital at Smolensk Station

Treatment tactics for colon cancer complicated by acute obstruction: comparison of short-term outcomes in right-sided and left-sided tumors

С. Н. Щаева, L. I. Volynets, N. S. Kryukov

Objectives. To evaluate of short-term outcomes of emergency surgeries for right-sided and left-sided colon cancer complicated by acute obstruction, to determine the independent predictors of postoperative complications. Material. A cohort retrospective study was performed, including 250 patients: group 1‑patients who underwent emergency …

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Incidence and Prognostic Value of Bone and Extramedullary Plasmacytomas in Patients with Newly Diagnosed Multiple Myeloma: Data from a Prospective Population-Based Study

M. V. Solovev, Л. П. Менделеева, Maiia Soloveva, Olga Samoilova et autres

BACKGROUND. The etiology of plasmacytomas in multiple myeloma (MM) remains unclear, whereas the pathogenetic mechanisms of extramedullary lesions are of particular importance because of extremely poor prognosis. The incidence of bone and extramedullary plasmacytomas complicating the course of MM as well as …

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Effectiveness and Safety of Lanadelumab in the Treatment of Patients with Hereditary Angioedema in Routine Clinical Practice in the Russian Federation.

Tatiana V. Nekrasova, L. V. Aleshina, Elena N. Bobrikova, Е. А. Викторова et autres

Background: Hereditary angioedema (HAE) caused by C1 inhibitor deficiency is a rare condition marked by recurrent swelling of the skin and mucous membranes. This study evaluated the effectiveness and safety of lanadelumab in routine clinical practice in Russia (IISR-2021-200085). Methods: A prospective …

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Experience with pegcetacoplan in patients with paroxysmal nocturnal hemoglobinuria and suboptimal response to C5 inhibitor therapy

Maria N. Finyakina, О. Ф. Никулина, Irina Galtseva, I. I. Mulina et autres

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal hematologic disorder whose pathogenesis is primarily driven by the formation of a cell clone (the PNH clone) lacking surface protective glycoproteins (CD55 and CD59), activation of the alternative complement pathway, and complement-mediated destruction …

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Post-intensive care syndrome: the role of pulmonary tissue density maps in acute pulmonary injury

A. V. Bormyshev, Т. Г. Морозова, A. V. Kovalev

Aim: to determine the diagnostic role of lung tissue density maps in acute lung injury (ALI) in the assessment of Post-Intensive Care Syndrome (PICS) in patients in the intensive care unit. Materials and Methods. 129 patients who were in inpatient and outpatient …

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Epidemiological and clinical features of multiple myeloma in Russia: results of a multicenter prospective study

M. V. Solovev, L. P. Mendeleeva, M. V. Soloveva, O. S. Samoylova et autres

Background. Epidemiological studies aggregating data on newly diagnosed multiple myeloma (MM) from real-world clinical practice allow to analyze various clinical and laboratory parameters characterizing general trends in MM diagnosis, treatment outcomes, and life expectancy. Aim. To determine overall survival rates in patients …

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Clinical Presentation and Chest CT Abnormalities in Adults with Mycoplasma Pneumoniae CAP During the 2023-2024 Outbreak

Olga Kupriushina, Rifat Aynetdinov, Svetlana Rachina, Daria Strelkova et autres

Background: (MCAP). Methods: We prospectively collected data on hospitalized adults with MCAP during the 2023-2024 outbreak. Clinical manifestation, laboratory data, and radiological abnormalities were evaluated. The data were analyzed using descriptive statistics. Results: A total of 40 patients were enrolled, with a …

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THE ATOPIC DERMATITIS: HISTORY OF THEORY, PRACTICAL BASIS AND CLASSIFICATION FROM BEGINNING OF ERA TO INTERNATIONAL CLASSIFICATION OF DISEASES: PUBLICATIONS REVIEW

Н. А. Конышко, D.A. Matveeva, G.C. Konyshko, L. I. Volynets et autres

The alarming trend in modern epidemiology of atopic dermatitis is omnipresent steady increase in its prevalence making the problem relevant. The purpose of the study is to shed light on historical aspects of development of ideas about atopic dermatitis and differences in …

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The Efficacy and Safety of BCD-180, an Anti-TRBV9+ T cell Monoclonal Antibody, in Patients with Active Radiographic Axial Spondyloarthritis: 36-week Results from the Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Study ELEFTA

Е. Л. Насонов, Mazurov Vi, А. М. Лила, Т. В. Дубинина et autres

The study aims to evaluate the clinical efficacy, safety, pharmacokinetics, pharmacodynamics and immunogenicity of seniprutug (BCD-180) in patients with active radiographic axial spondyloarthritis (r-axSpA, or ankylosing spondylitis). MATERIALS AND METHODS: Two hundred sixty patients with active r-axSpA and inadequate response to nonsteroidal …

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The Efficacy and Safety of Divozilimab in Patient with Systemic Sclerosis: 48-Week Results of the Randomized Double-Blind Placebo-Controlled Phase III Clinical Study LIBERIUS

L. P. Ananyeva, M. Starovoytova, I. Z. Gaydukova, G. Lukina et autres

of the study is to evaluate the efficacy, safety, and immunogenicity of divozilimab (DIV), anti-CD20 monoclonal antibody, in patients with systemic sclerosis (SS). MATERIALS AND METHODS: Patients with SS according to ACR/EULAR (American College of Rheumatology/European Alliance of Associations for Rheumatology) 2013 …

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Coronary pulmonary fistulas, their role in impaired coronary and systemic hemodynamics, the development of myocardial ischemia on the example of patients in cardiology departments

Coronary pulmonary fistulae are rare abnormalities of coronary artery development, can be combined with other heart defects and, depending on diameter, are hemodynamically significant or not. To date, the question of the role of coronary pulmonary fistulas in the development of acute …

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Zieve syndrome: the history of the eponym, the description of the case

С.В. Ковалев

Background. In 1958, the American physician Leslie Zieve first presented at a conference, and then described the original hepatological syndrome, which he observed in a series of clinical cases – and subsequently this pathology was called "Zieve syndrome". The disease is noted …

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