Eli Lilly (Ireland)

Selenium in Aging and Longevity

William Gerard Pierce, John J. Mackrill

Selenium is an essential dietary micronutrient, exerting beneficial effects over a limited range of concentrations. Insufficient dietary intake of selenium increases the risk of type 2 diabetes, infertility, immune dysfunction, prostate cancer, cognitive decline, prostate cancer, colorectal cancer in females, skeletal muscle …

ie (code pays fourni par la source)

Liver Fat Changes in Patients With Type 2 Diabetes by Presence of Genetic Hepatic Steatosis: A Post Hoc Analysis of SURPASS ‐3 MRI

Kenneth Cusi, Amalia Gastaldelli, Laura Fernández Landó, Palash Sharma et autres

ABSTRACT The patatin‐like phospholipase 3 (PNPLA3) I148M genetic variant is highly associated with steatotic liver disease. In the SURPASS‐3 MRI substudy, tirzepatide significantly reduced liver fat content (LFC) versus insulin degludec in insulin‐naïve patients with type 2 diabetes with metabolic dysfunction‐associated steatotic …

us, it, ie, es (code pays fourni par la source)

Identifying Pregnancies in Population‐Based Data Sources: Development and Application of the ConcePTION Pregnancy Algorithm

Giorgio Limoncella, Anna Girardi, Claudia Bartolini, Giulia Hyeraci et autres

PURPOSE: In 2019, the Innovative Medicines Initiative funded the ConcePTION project to enhance monitoring of medication safety in pregnancy and breastfeeding. This paper describes how the ConcePTION Pregnancy Algorithm (PA) identified pregnancies in 10 diverse European electronic healthcare data sources and estimated …

it, es, nl, us, fr, gb, no, Maroc, ie, dk (code pays fourni par la source)

Characterising patients with Alzheimer’s disease in England: a cohort study using data from Clinical Practice Research Datalink linked to Hospital Episode Statistics

Ana Sofía Afonso, Krista Schroeder, Lucy Mitchell, Natacha Carragher et autres

OBJECTIVES: To characterise demographics, comorbidities, co-medications and healthcare resource utilisation (HCRU) in patients newly diagnosed with Alzheimer's disease (AD) in England using published and validated AD algorithms. DESIGN: Observational cohort study. SETTING: Real-world data in England from the Clinical Practice Research Datalink …

nl, us, gb, ie (code pays fourni par la source)

LFP snippets from the perforant path stimulation rat model of temporal lobe epilepsy

Vanessa Schütz, Lara Costard, Valentin Neubert, M. Strüber

Matlab file containing LFP sections before, during and after perforant pathway stimulation recorded in the perforant path stimulation rat model of temporal lobe epilepsy. Accompanying data set to the manuscript "Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy", accepted for …

ie, de (code pays fourni par la source)

LFP snippets from the perforant path stimulation rat model of temporal lobe epilepsy

Vanessa Schütz, Lara Costard, Valentin Neubert, M. Strüber

Matlab file containing LFP sections before, during and after perforant pathway stimulation recorded in the perforant path stimulation rat model of temporal lobe epilepsy. Accompanying data set to the manuscript "Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy", accepted for …

ie, de (code pays fourni par la source)

TIRZEPATIDE TREATMENT AND ACHIEVING WEIGHT REDUCTION ›5%, SBP REDUCTION ›5 MMHG AND NON–HDL CHOLESTEROL REDUCTION ›10%: A POST–HOC ANALYSIS FROM THE SURMOUNT–1 3–YEAR TRIAL

N Sattar, C Le Roux, M Mamas, H Wang et autres

Abstract Introduction This post–hoc analysis evaluated the proportion of participants with obesity and prediabetes who met the combined goal of weight reduction ›5%, systolic blood pressure (SBP) reduction ›5 mmHg and non–HDL cholesterol reduction ›10% from baseline to Week 176 in SURMOUNT–1 …

ie, gb (code pays fourni par la source)

P166 High body mass index psoriasis is associated with higher prevalence of cardiometabolic disease, psoriatic arthritis, and systemic inflammation

Joseph F Merola, M Lebwohl, Christopher E M Griffiths, Yukari Okubo et autres

Abstract Background/Aims Psoriasis and obesity share inflammatory pathways, suggesting a bidirectional relationship with overlapping comorbid complications that can impact overall patient health. This analysis evaluated baseline data from 17 clinical trials of patients with moderate-to-severe psoriasis to assess baseline comorbidities across the …

us, gb, jp, ie (code pays fourni par la source)

Polarity- and Sequence-Dependent Ionization of Therapeutic Antibody–siRNA Conjugates: Enabling Intact Multi-attribute Method for Comprehensive Characterization and Identity Release Assay

Hao Liu, Jamie L. Veltri, P. Clayton Gough, Sean O. Crowe et autres

High Resolution Image Download MS PowerPoint Slide Antibody–siRNA conjugates (ARCs) represent a promising approach for delivering small interfering ribonucleic acids (siRNAs) to targeted cells, tissues, or organs. The complexity of the molecules poses great analytical challenges in identifying, characterizing, and monitoring their …

us, Afrique du Sud, ie (code pays fourni par la source)

Insights into Flow and Continuous Systems in Pharmaceutical Manufacturing: Challenges and Opportunities

Adrian M. Daly, Seán Hardiman, David Hogan, Gary Morris et autres

Growth and development of the pharmaceutical sector in Ireland has been remarkable over a 50 year period starting as an API manufacturing hub with strong regulatory confidence gradually expanding to include a range of activities ranging from process R&D, formulation services, and …

us, ie, gb, ch (code pays fourni par la source)

Efficacy of Pirtobrutinib Monotherapy in Treatment-Naïve Chronic Lymphocytic Leukemia: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

Toby A. Eyre, Lisa M. Hess, Ehsan Masoudi, Min-Hua Jen et autres

BACKGROUND: There are multiple effective treatment options for patients diagnosed with chronic lymphocytic leukemia and small lymphocytic lymphoma (hereafter, simply CLL). In 2025, two phase 3 randomized clinical trials of pirtobrutinib, a non-covalent BTK inhibitor, were reported, demonstrating improved outcomes versus comparator …

gb, us, de, ie (code pays fourni par la source)

Contributors

Olalere Olusegun Abayomi, Wasiu Ayodele Abibu, Abdulhalim Musa Abubakar, F.O. Agaja et autres

gb, Nigéria, pk, kw, my, ae, us, tr, ie, Tunisie, de, Afrique du Sud, ca, es, in, cn, lt, th (code pays fourni par la source)