Wolfram Research (United Kingdom)

Consensus Recommendations for the Clinical Management of Wolfram syndrome Using a Delphi Method

Josephine Elliott, Saumel Ahmadi, Patrick Yu-Wai-Man, Sarah Gladstone et autres

Background: -Wolfram syndrome. Historically, it has been characterized by early-onset, antibody-negative, insulin-dependent diabetes mellitus, progressive optic atrophy, sensorineural hearing loss, arginine vasopressin deficiency, and brainstem and cerebellar atrophy. More recently, partial and late onset forms have been identified. There are currently no …

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Certified Arbitrary-Precision Evaluation of a Family of Generalized Multiple Zeta Functions

Jayanta Phadikar

We describe a certified arbitrary-precision framework for evaluating a family of generalized multiple zeta functions. The family includes strict and weak-star chain sums, ordinary and colored multiple zeta values, affine-base and polynomial-base variants, and composite levels containing several affine or polynomial letters …

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CalebBell/chemicals: v1.5.2

Caleb Bell, Yoel, Viraj Desai, Je Sian Keith Herman et autres

What's Changed Add COSTALD_mixture_compressed() to volume.py __all__ init by @jskherman in https://github.com/CalebBell/chemicals/pull/74 Enhancements/bug-fix to combustion module by @yoelcortes in https://github.com/CalebBell/chemicals/pull/75 New release PR by @CalebBell in https://github.com/CalebBell/chemicals/pull/76 Full Changelog: https://github.com/CalebBell/chemicals/compare/v1.5.1...v1.5.2

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Monoidal Alphabets for Generalized Harmonic Sums

Jayanta Phadikar

We develop a general finite-alphabet framework for Euler-type sums based on the notion of a monoidal alphabet. An alphabet of summand letters is called monoidal when it is closed under pointwise multiplication, thereby inducing the usual stuffle, or quasi-shuffle, algebra on the …

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Abstract 4261: High-sensitivity HLA-I immunopeptidome profiling from limited clinical PBMC samples

Anamarija Pfeiffer, Lucy F. Yang, Arthur Viodé, Daniel Redfern et autres

Abstract Background: Human leukocyte antigen (HLA) molecules are central to immune surveillance, presenting antigenic peptides from self and non-self proteins to T cells, and directing adaptive immune responses. Assessment of HLA-presented peptides is increasingly critical in oncology, both for understanding tumor immunogenicity …

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Abstract 1768: High-sensitivity targeted mass spectrometry enables quantification of HLA-presented antigens for TCR-T therapeutic target discovery

Simonas Savickas, Anamarija Pfeiffer, Arthur Viodé, Liliana Malinovska et autres

Abstract Background: Human leukocyte antigens (HLA) are key mediators of adaptive immunity, presenting antigenic peptides derived from self and non-self proteins for immune surveillance. Tumor-specific neoantigens generated by somatic mutations represent key determinants of immune recognition and are central to the development …

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A universal survival front for close-in exoplanets from summed tidal and thermal hazards

Vitaliy Kaurov

We present a survival-front framework for the close-in inner edge of exoplanet systems. The observed innermost-survivor boundary is modeled as the projected trace of a critical surface $H(q,L_\star,M_\star)=1$ in periapsis-luminosity-mass space, with dimensionless headroom coordinates $X$ and $Y$ that organize irradiation and …

gb (code pays fourni par la source)

A universal survival front for close-in exoplanets from summed tidal and thermal hazards

Vitaliy Kaurov

We present a survival-front framework for the close-in inner edge of exoplanet systems. The observed innermost-survivor boundary is modeled as the projected trace of a critical surface $H(q,L_\star,M_\star)=1$ in periapsis-luminosity-mass space, with dimensionless headroom coordinates $X$ and $Y$ that organize irradiation and …

gb (code pays fourni par la source)

CalebBell/chemicals: v1.5.1

Caleb Bell, Yoel, Viraj Desai, Je Sian Keith Herman et autres

What's Changed feat: Add pressure dependence to COSTALD_mixture() by @jskherman in https://github.com/CalebBell/chemicals/pull/72 release 1.5.1 by @CalebBell in https://github.com/CalebBell/chemicals/pull/73 New Contributors @jskherman made their first contribution in https://github.com/CalebBell/chemicals/pull/72 Full Changelog: https://github.com/CalebBell/chemicals/compare/v1.5.0...v1.5.1

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Should emotional labour be a critical component in healthcare workforce modelling?

Cidalia Das Neves Eusebio, Alison Leary, Joseph A. Brennan, Sue R. Pavord et autres

ABSTRACT Healthcare work is emotionally intensive, yet emotional labour is overlooked in workforce modelling, with significant impact in terms of burnout and staff retention. The aim of this study was to examine emotional labour expenditure in a multi-professional group working in a …

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1561P EMITT-1: Final clinical, PK & PD data from dose escalation and selection of recommended dose for expansion cohorts in a phase I study of GRWD5769 (a first-in-class ERAP1i) in patients with solid malignancies

J.J. Liu, Ganessan Kichenadasse, Teresa Cenarro Guerrero, Emiliano Calvo et autres

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Abstract 5838: Quantification of ERAP-1 inhibition-dependent HLA-I peptides using targeted mass spectrometry for TCR-based therapeutics target discovery

Anamarija Pfeiffer, Lucy F. Yang, Maik Mueller, Daniel Redfern et autres

Abstract Human leukocyte antigens (HLA) play a central role in orchestrating immune responses by presenting antigenic peptides derived from both self and foreign proteins. The identification of neoantigens, unique to individual tumors due to somatic mutations, has become a focal point in …

ch, gb (code pays fourni par la source)