Non‑nucleoside inhibitors of SARS‑CoV‑2 RdRp identified by high‑throughput screening and an approach to their mechanism of action by comparative studies
Shangqian Wu, Chuwei Yang, Dongying Li, Yuzheng Zhou et autres
Abstract The RNA-dependent RNA polymerase (RdRp) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pivotal antiviral target due to its essential role in viral replication and high conservation. Non-nucleoside analog inhibitors (NNIs) are a promising class of antiviral compounds that …
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npj Antimicrobials and Resistance