Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations
William Rae, John M. Sowerby, Dorit Verhoeven, Mariam Youssef et autres
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a central regulator of immunity. TRAF3 is often somatically mutated in B cell malignancies, but its role in human immunity is not defined. Here, in five unrelated families, we describe an immune dysregulation syndrome …
gb, nl, ca, us, Soudan du Sud, vn, mx (code pays fourni par la source)
1 citation
PubMed Central