Prognostic Markers in Meningioma: Effectiveness of FISH‐Assessed CDKN2A/B Homozygous Deletion and Limits of Surrogate p16/MTAP Immunohistochemistry in Predicting Disease‐Specific Survival
Alessia Andrea Ricci, Filippo Nozzoli, Alessandro Biale, Cristian Tampieri et autres
AIMS: Homozygous deletion (HD) of CDKN2A/B represents an adverse prognostic biomarker in meningiomas and a diagnostic criterion for CNS WHO grade 3 assignment. However, fluorescence in situ hybridisation (FISH) thresholds and the role of immunohistochemistry (IHC) surrogates remain uncertain. This study evaluated …
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Neuropathology and Applied Neurobiology