NRG1 fusions in non-small cell lung cancer: biology, diagnostics, and emerging HER2/HER3 therapies—a narrative review
Andrea Marini, I. Stasi, Antonio Pellino, Enrico Sammarco et autres
Background and Objective: NRG1 gene fusions are rare but clinically relevant oncogenic drivers in non-small cell lung cancer (NSCLC) and drive tumorigenesis through ligand-dependent activation of HER2/HER3 signaling. In contrast to kinase-driven oncogenic fusions, NRG1 alterations preserve the EGF-like domain that can …
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Translational Lung Cancer Research