Inhibition of CPT1A Enhances Doxorubicin and Vincristine Efficacy in Diffuse Large B-cell Lymphoma Cells
Sophia Steinlein, Annette M. Staiger, Katrin S Kurz, Viola Poeschel et autres
Therapy resistance in diffuse large B-cell lymphoma (DLBCL) is mediated, in part, by stromal protection of malignant B cells.Carnitine palmitoyltransferase 1A (CPT1A) is a key regulator of fatty acid transport into mitochondria, including fatty acids supplied by stromal cells, thereby supporting lymphoma …
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