Association of PDGFRB, VEGFR2, and TGFB1 Gene Polymorphisms with Nintedanib Efficacy and Adverse Effects in Patients with Progressive Pulmonary Fibrosis
Natasa Djurdjevic, Marija Dušanović Pjević, Mihailo Stjepanović, Nikola Čolić et autres
Progressive pulmonary fibrosis (PPF) comprises interstitial lung diseases characterized by progressive fibrosis and lung function decline. Nintedanib slows disease progression by inhibiting FGFR, VEGFR, and PDGFR signaling, but treatment response varies among patients. We investigated whether VEGFR2, PDGFRB, and TGFB1 gene variants …
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International Journal of Molecular Sciences