The private truncating Toll-like receptor 7 p.Glu834* variant associates with juvenile-onset systemic lupus erythematosus and pathological cytokine expression in vitro
Yves Renaudineau, Jenny Hawkes, Katarzyna Mizgalska, Valentina Natoli et autres
OBJECTIVES: The X chromosome-linked Toll-like receptor (TLR)7 gene contributes to type I interferon (IFN) expression in systemic lupus erythematosus (SLE). Recently, ultra-rare variants in TLR7 have been linked with Mendelian forms of SLE. METHODS: Targeted new-generation sequencing was used to identify TLR7 …
fr, gb, us (code pays fourni par la source)
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Annals of the Rheumatic Diseases