Tumor-tropic E. coli engineered as living T and NK cell engagers
Shaobo Yang, Anna Clara Bader, Stephanie Sendker, Ashley Hu et autres
Abstract Despite advances in immunotherapy, most solid tumors remain resistant to treatment. Immune cell engagers redirect cytotoxic lymphocytes against cancer, but limited tumor access, immunosuppressive microenvironments and systemic immune activation limit efficacy. Here we develop live immune modulating engagers (LIME), a modular …
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bioRxiv (Cold Spring Harbor Laboratory)