Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk
Ana B. Nunez-Nescolarde, Yang Liao, Laura Perlaza-Jiménez, Mehran Piran et autres
BACKGROUND: Acute kidney injury (AKI) is a common clinical syndrome associated with high morbidity and progression to chronic kidney disease. Ischaemia is a leading cause of AKI, driving cellular stress, metabolic reprogramming, and injury-associated epithelial states. Scalable human models that enable controlled …
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Genome Medicine