Integrative proteogenomics and forward genetics reveals a novel mitotic vulnerability in triple-negative breast cancer.
Susan G Hilsenbeck, Siddhartha Tyagi, Shayan C. Avanessian, Nicholas J. Neill et autres
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with few effective targeted therapies. Taxanes and other microtubule-targeting agents (MTAs) are frontline chemotherapies for TNBC; however, the molecular pathways that cause TNBC taxane sensitivity are largely unknown, preventing selection of …
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