Depletion of an immature cord blood NK subset reverses trogocytosis-driven CAR NK dysfunction
Ye Li, Huihui Fan, Guohui Wang, Xin Wang et autres
Allogeneic CAR-engineered NK cells enable scalable off-the-shelf therapy, yet donor heterogeneity remains a major barrier to consistent potency. Building on our clinical experience with cord blood-derived CAR NK cells, we identified an immature CD16 − CD161 − double-negative (DN) NK subset associated …
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Cancer Cell