The DR-DQ HLA haplotypes dominant-recessive interplay leads to the heterogeneity of antibody immune response in T1D
Elizaveta A. Telnaya, Ekaterina S. Petriaikina, Zoia G Antysheva, Dmitry Tychinin et autres
Abstract Type 1 diabetes mellitus (T1D) is an autoimmune disorder defined by the presence of islet-specific autoantibodies (AAb). Growing evidence indicates substantial heterogeneity in T1D pathogenesis, reflected in divergent AAb profiles across patient subgroups. We integrated ELISA-based measurements of four major islet …
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Communications Biology