Jin P. Szatkiewicz

Neurodevelopmental Impact of Copy Number Variants in Patients With Treatment-Resistant Schizophrenia

Wenxin Bian, Rose Mary Xavier, Tyler E Dietterich, Xun Zhou et autres

Copy number variations (CNVs) are a major contributor to the etiology and phenotypic variability in schizophrenia. CNVs are also independently associated with certain neurological, cognitive, and behavioral conditions, yet their role in early neurodevelopment in the context of treatment-resistant schizophrenia remain largely …

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Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes

et D. Termorshuizen, Helena L. Davies, Sang-Hyuck Lee, Jessica K. Dennis et autres

We conducted a genomic meta-analysis of case–control studies of binge-eating behavior (BE; 39,279 cases, 1,227,436 controls), alongside analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six BE-associated loci, including loci associated with a higher body …

Shared genetic risk between eating disorder- and substance-use-related phenotypes : Evidence from genome-wide association studies

Melissa A. Munn‐Chernoff, Emma C. Johnson, Sarah E. Medland, Stéphanie Le Hellard et autres

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J. Vilhjálmsson, Jian Yang, Hilary K. Finucane, Alexander Gusev et autres

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