Prior therapy defines mutation profiles in childhood cancer at relapse
Mehdi Layeghifard, Marcos Díaz‐Gay, Erik N. Bergstrom, Mathepan J. Mahendralingam et autres
Children with cancer develop many short- and long-term side-effects of treatment1, but the amount of DNA damage associated with chemotherapy exposure is unclear2. Here we used mutational signatures to measure this damage using whole-genome-sequenced tumours from a multi-institutional cohort for which therapy …
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Nature