Single-cell multi-omic analyses resolve the cellular diversity of ALK/ROS1/MET/NTRK-fused gliomas in infants and older children
Andrea J. De Micheli, Carlos O.A. de Biagi-Junior, Costanza Lo Cascio, Charbel Machaalani et autres
Pediatric cancers are thought to arise from dysregulation of developmental programs, otherwise tightly regulated in time and space. Infant-type hemispheric gliomas (IHGs) arise in early childhood, driven by characteristic ALK/ROS1/MET/NTRK receptor tyrosine kinase (RTK) gene fusions. We dissected the cellular hierarchies of …
ch, us, cz, ca, gb, in, at, fr (code pays fourni par la source)
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bioRxiv (Cold Spring Harbor Laboratory)