M. Fortunato

Incorporating Pathomics Into IgAN Risk Prediction

David L. Hölscher, Sean J. Barbour, Rosanna Coppo, Lee Er et autres

Introduction: IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide, with heterogeneous progression rates. The International IgAN Prediction Tool (IIgAN-PT) enables individualized risk prediction using clinical characteristics and histopathological scoring. However, traditional histopathological scoring is semiquantitative and prone to interobserver variability. Deep …

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Individualised treatment effects of corticosteroids in IgA nephropathy

David L. Hölscher, Nikolas E.J. Schmitz, Leon Niggemeier, Pourya Pilva et autres

BACKGROUND: IgA nephropathy (IgAN) has diverse clinical presentations and responses to treatment. For systemic corticosteroids in particular, randomised controlled trials have reported conflicting effects, highlighting the need for individualised treatment strategies. METHODS: In this retrospective cohort study, we derived and validated a …

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Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy

Shubha S. Bellur, Stéphan Troyanov, Olga A. Vorobyeva, Rosanna Coppo et autres

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