Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis
Shuai Sun, Yan Xu-yang, Yuhang Dong, Jian‐min You et autres
The inflammatory response resulting from the abnormal accumulation of metabolites has been implicated in the pathogenesis of organ fibrosis; however, its role and underlying mechanisms in renal fibrosis remain unclear. In this study, we observed a negative correlation between fumarate hydratase (FH) …
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Journal of Clinical Investigation