Lipa regulates myeloid differentiation and is essential for intra-plaque macrophage accumulation during atherogenesis
Tianhan Li, Juanjuan Qiu, H Zhang, Jianjun Wu et autres
Lysosomal acid lipase ( LIPA ), one of the earliest and most impactful genetic factors linked to human coronary artery diseases, is highly expressed in macrophages despite predominant hepatic production. However, the functional importance of LIPA in macrophages remained largely unknown. Notably, …
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