Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection
Pratibha Jagannatha, Yoseop Yoon, Samuel Landry, Jack T. Naritomi et autres
Alternative polyadenylation (APA) generates transcript isoforms with distinct 3' ends, yet the repertoire of its protein regulators remains poorly defined. Using a large-scale tethered function screen, we profiled 879 human RNA-binding proteins (RBPs) and identified 63 high-confidence activators of poly(A) site (PAS) …
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Molecular Cell