Aquaporin-1 (AQP1) mediates cardiac oedema and mitochondrial dysfunction in cardiometabolic HFpEF: New insights into the mechanisms of SGLT2 inhibitors
Shilin Guan, Xiaoyue Sun, Yingxin Huang, Yongmei Li et autres
Myocardial oedema contributes significantly to cardiomyocyte dysfunction and death. A 3.5 % increase in water content can result in a 30–50 % reduction in cardiac output. Myocardial oedema is an early complication of prediabetes and is associated with ventricular remodelling and diastolic …
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Biochemical Pharmacology