Single-cell transcriptomics reveals the prognostic and immune infiltration significance of FOLFOX-bevacizumab treatment and lysine crotonylation characteristics in colon cancer
Shiyang Zhan, Shurong Huang, Yangqiang Wang, Wei Zheng et autres
Background: Colon cancer (CC), a malignant tumor originating from the colonic mucosal epithelium, frequently exhibits limited efficacy in advanced patients undergoing first-line FOLFOX (oxaliplatin, leucovorin, and 5-fluorouracil)-bevacizumab (FOLFOX-Bev) therapy due to resistance. Lysine crotonylation (Kcr), a novel histone post-translational modification, regulates gene …
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Journal of Gastrointestinal Oncology