2026
conference-abstract
OpenAlex
Jessica A. Beck, Anjali Garg, Lauren E. McGee, Elijah Edmondson et autres
Abstract Background: Osteosarcoma (OS) is a rare pediatric malignancy (<1,000 cases/year) but occurs frequently in pet dogs (>10,000 cases/year), providing a valuable comparative model. Human and canine OS share molecular, clinical, and histologic features, as well as standard-of-care treatments (chemotherapy with limb …
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Accès ouvert
2026
article
OpenAlex
Yuelin Liu, Anton Goretsky, Ayşe Gökçe Keşküş, Salem Malikić et autres
Tumor evolution is driven by various mutational processes, ranging from single-nucleotide variants (SNVs) to large structural variants (SVs) to dynamic shifts in DNA methylation. Current short-read sequencing methods struggle to accurately capture the full spectrum of these genomic and epigenomic alterations due …
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2026
preprint
OpenAlex
Hsin-Pei Lee, Meng Liu, Wenqi Wu, Ngoc Thao Lam Nguyen et autres
Abstract Tumor spatial organization critically shapes disease progression and therapeutic response, yet remains poorly defined. Intrahepatic cholangiocarcinoma (iCCA), a rare and aggressive liver malignancy with extensive stromal and immune remodeling, provides a compelling model to study tumor architecture. We generated a single-cell …
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