Pleiotropic shared heritability quantifies the shared genetic variance of common diseases
Yujie Zhao, Benjamin J. Strober, Kangcheng Hou, Gaspard Kerner et autres
Abstract The overall contribution of pleiotropy to disease architectures is unknown, as most studies estimate genetic correlations with each auxiliary disease in turn. Here we propose a method—pleiotropic shared heritability with bias correction (PHBC)—to estimate the liability-scale genetic variance of a target …
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1 citation
Nature Genetics