Lena F. Burbulla

Loss of Fragile X Protein Impacts α-Synuclein Homeostasis via Insulin-Degrading Enzyme in Parkinson’s Disease

Pan Gao, Yiyang Wu, Svenja-Lotta Rumpf, Weilin CHEN et autres

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Aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia

Gamze Özata, Rachel M. Wise, Aida Cardona‐Alberich, Naiyareen F. Mayeen et autres

Microglia are the brain's resident immune cells, essential for homeostasis and implicated in common neurodegenerative diseases like Alzheimer's and Parkinson's disease (PD), where their early activation and sustained inflammatory mediator release contribute to neuronal loss. However, their role in rare disorders is …

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Genetic variation in antidiabetic drug targets: associations with Parkinson’s disease risk and age at onset

Katalin Vincze, Agnieszka Szwajda, Alexander Ploner, Robert Karlsson et autres

To investigate whether antidiabetic drugs have a biological basis to be repurposed in PD prevention, we applied a drug target Mendelian randomization framework to assess associations between genetic variation in antidiabetic drug targets and PD risk or age at onset (AAO). Instrumental …

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