A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing
Yehui Sun, Yu-Chung Pien, Yufen Xiao, Wei Tan et autres
RNA therapeutics offer promising potential for treating heart disease; however, their clinical application has been limited by insufficient cardiac delivery. Here, we developed a screening platform using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to identify human cardiotropic lipid nanoparticles (LNPs). By …
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Proceedings of the National Academy of Sciences