Accès ouvert
2026
article
OpenAlex
Mei Wu, Xi Luo, Pei‐Yu Jiang, Qian Xu et autres
Ricin, a highly toxic protein derived from Ricinus communis, is recognized as a biological threat due to its high toxicity and the absence of approved specific antidotes. Monoclonal antibodies (mAbs) represent an emergency therapeutic for ricin intoxication. However, the short therapeutic window …
cn
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2026
preprint
OpenAlex
Yi-Jiao Huang, Lu Lv, Wei Ran, Hongyun Zhao et autres
Abstract The spike protein of highly pathogenic coronaviruses is indispensable for viral entry, pathogenesis, and immune evasion. However, specific host factors governing spike protein degradation and abundance on progeny virions remain largely uncharacterized. Here, we identify Ribophorin-1 (RPN1), a non-catalytic subunit of …
cn
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Accès ouvert
2026
article
OpenAlex
Chao Zhou, Meng-Li Cheng, Meng-Jiao He, Yao Liu et autres
Zika virus (ZIKV) remains a significant public health threat due to its pronounced neurotropism linked to Congenital Zika Syndrome (CZS). Paradoxically, the same neurotropism also provides a unique opportunity for exploiting ZIKV as an oncolytic agent against malignant brain tumors such as …
cn
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