Oliver Wieben

Elevated Cerebral Pulsatility Is Associated With Lower Brain Region Volumes In Veterans With Gulf War Illness

Sarean Harmoni A. Gaynor‐Metzinger, Paul F. Baumhardt, John Christopher D. Baron, Andrew G. Pearson et autres

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Impact of vertebral artery hypoplasia on cerebrovascular reactivity

Zhilun Zhou, Brandon G. Fico, M. Erin Moir, Anna Howery et autres

Vertebral artery hypoplasia (VAH) is one of the most common anomalies of cerebrovascular structure and is present among healthy asymptomatic individuals. The prevalence of VAH is estimated to be between 15% and 35%. Although VAH has been associated with regional hypoperfusion in …

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Temporal Dynamics of Cerebral Blood Flow Reductions During Isocapnic Hyperoxia: The Role of Reactive Oxygen Species

Hedyeh Khademi Motlagh, Logan Heenan, Andrés Ortíz, Kaylin Didier et autres

Background: Hyperoxia is frequently used as medical treatment for, and prophylaxis to, hypoxia/ischemia-related conditions. In the brain, hyperoxia reduces cerebral blood flow (CBF), possibly through oxidative stress from reactive oxygen species (ROS) that disrupt vascular function; an effect that may intensify with …

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Exploring potential sex differences in cerebral blood flow responses to hyperoxia

Kritika Kakade, Hedyeh Khademi Motlagh, Kaylin Didier, Logan Heenan et autres

Background: Hyperoxia, oxygen-enriched inhalation, is used in clinical settings to support impaired cerebral oxygenation, like traumatic brain injury. However, hyperoxia can paradoxically reduce cerebral blood flow (CBF); prior studies showed decreases up to 37%, potentially due to increases in reactive oxygen species …

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Biological sex impacts intracranial vasomotor and hemodynamic responses during light intensity exercise: a 4D flow MRI study

M. Erin Moir, Anna Howery, Alma Spahic, Adam Corkery et autres

Biological sex modifies cerebrovascular responses to physiological challenges such as chemical stimuli. Yet, the impact of biological sex on cerebrovascular responses to aerobic exercise remain unclear. This uncertainty stems, in part, from the reliance on intracranial blood velocity assessment which does not …

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