Targeting an RNA Editor to Impede H3K27M+ Pediatric Gliomas
Christian K Ramsoomair, Victoria Álvarez, Felipe Sarmiento, Manuela Aramburu Berckemeyer et autres
Diffuse midline glioma (DMG) is a lethal pediatric brain tumor with no curative therapies. Immune checkpoint blockade (ICB) has shown limited efficacy in DMG, largely due to poor T cell infiltration, low immune checkpoint (IC) expression, and a low tumor mutational burden. …
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bioRxiv (Cold Spring Harbor Laboratory)