Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution
Rongyu Zhang, Jingqi Qi, Michaela McKasson, Jongchan Choi et autres
Systematic whole-protein screening and comprehensive profiling of antigen-specific CD4+ T cells are crucial for advancing vaccine design and cancer immunotherapies, yet remain technically challenging. Here, we present a high-throughput platform that utilizes large-scale class II single-chain trimer libraries to detect antigen-specific CD4+ …
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Nature Communications