CD4 + T cells impair tumor growth through IL-3 and TNF-dependent vascular damage
Qiaoshi Lian, Jia Nie, Jatinder Singh, Qiang Chen et autres
Most cancer immunotherapy strategies are focused on direct tumor killing by immune cells, especially T lymphocytes. Clinical and conceptual limitations of these approaches create a need for additional strategies. We identified a tumor stroma–targeting mechanism in which tumor antigen–specific CD4 + T …
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