Hawazen Alsaedi

Hematopoietic stem cell transplantation for DOCK8 deficiency: durable immune reconstitution and long-term survival in 47 patients

Bashayr Alanazi, Reem Mohammed, Ali Al-Ahmari, Nora Alrumayan et autres

Background DOCK8 deficiency is a severe autosomal recessive combined immunodeficiency characterized by recurrent infections, severe atopy, immune dysregulation, and an increased risk of malignancy. Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment. We aimed to evaluate the long-term survival, …

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Hematopoietic Stem Cell Transplantation in Children With Transfusion Dependent β‐Thalassemia: A Two‐Decade Single‐Center Experience

Abdullah Al‐Jefri, Khawar S. Siddiqui, Murtada Al‐Sultan, Sami Al‐Otaibi et autres

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Clinical Phenotype and Hematopoietic Stem Cell Transplantation Outcomes in AK2-Related Reticular Dysgenesis: A Single-Center Experience

Bothainah Alaqeel, Faiz Aljohani, Nora Alrumayan, Ali Al-Ahmari et autres

Background Reticular dysgenesis (RD) is the most severe and rarest form of severe combined immunodeficiency (SCID), characterized by profound defects in both lymphoid and myeloid lineages and caused by biallelic pathogenic variants in AK2. Due to its rarity, data on the clinical …

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Reticular dysgenesis caused by AK2 deficiency: clinical spectrum and hematopoietic stem cell transplantation outcomes in 10 patients from a single-center

Bothainah Alaqeel, Faiz Aljohani, Nora Alrumayan, Ali Al-Ahmari et autres

Introduction Reticular dysgenesis (RD), caused by biallelic variants in AK2 , represents the most severe and rare form of Severe Combined Immunodeficiency, characterized by profound defects in lymphoid and myeloid lineages; however, data on its clinical spectrum and hematopoietic stem cell transplantation …

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