Scalable genotyping in fixed transcriptomes resolves clonal heterogeneity via single-cell sequencing
Sydney B. Blattman, Nabih Maslah, Austin Varela, Karolis Kumpaitis et autres
Abstract Despite the promise of single-cell transcriptomics for understanding cell states in heterogeneous populations, widely used platforms have limited ability to link transcriptional states to somatic mutations within the same cells. Here, we introduce Genotyping in Fixed Transcriptomes (GIFT) for the simultaneous …
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bioRxiv (Cold Spring Harbor Laboratory)