NLRP14 modulates the activity of E3 ubiquitin ligases during the oocyte-to-embryo transition
Sibei Liu, Qianqian Qi, Pengliang Chi, Haizhan Jiao et autres
NLRP14 is an essential maternal factor for mammalian embryonic development. Maternal ablation of NLRP14 in mice impairs DNA demethylation and calcium homeostasis in zygotes, causing early embryonic arrest. However, the underlying biochemical events remain largely unknown. Here, we identified two binding partners …
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Nature Communications