Polycomb repressive complex 2 insufficiency underlies myeloid leukemia in Down syndrome
Yutaro Suzuki, Yaeko Nakajima-Takagi, Motohiko Oshima, Yotaro Ochi et autres
ABSTRACT: Children with Down syndrome (DS) have an elevated risk of developing myeloid leukemia (ML; ML in DS [ML-DS]). In addition to mutations in GATA1, which generate the truncated isoform GATA1-short (GATA1s), ML-DS requires additional somatic gene mutations, most frequently in cohesion …
jp, us (code pays fourni par la source)
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Blood