Abstract 3149: Micronuclei (MN) dynamics in preclinical models and in patient reticulocytes as a pharmacodynamic biomarker for the first in class DNA polymerase theta (PolΘ) inhibitor ART6043
Colette L Baxter, Timothy A. Yap, Susanna V. Ulahannan, Nehal J. Lakhani et autres
Abstract Introduction: ART6043 is a first in class, potent and selective polymerase domain inhibitor of DNA Polθ, a central mediator of the microhomology-mediated end joining (MMEJ) DNA double strand break (DSB) repair pathway. Novel biomarkers are important to demonstrate target engagement of …
gb, us (code pays fourni par la source)
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Cancer Research