2026
conference-abstract
OpenAlex
Humeyra Kaanoglu, Yasemin Kübra Akyel, Adebimpe Adefolaju, Alain Valdivia et autres
Abstract Background: Glioblastoma (GBM) remains highly lethal despite surgery, radiotherapy, and temozolomide (TMZ). We identified a therapeutic role for 5-ethynyl-2′-deoxyuridine (EdU), a thymidine analog whose incorporation is recognized and excised by nucleotide excision repair (NER). We hypothesized that combining TMZ (lesions processed …
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2026
conference-abstract
OpenAlex
Xiaopei Zhang, Breanna Mann, Adebimpe Adefolaju, Alain Valdivia et autres
Abstract Adoptive T cell therapies, including chimeric antigen receptor (CAR) T cells, have shown limited success in solid tumors, largely due to widespread preclinical models that fail to capture patient tumor heterogeneity and the immunosuppressive tumor microenvironment (TME). Conventional systems, including cell …
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(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Breanna Mann, Nichole Artz, Adebimpe Adefolaju, Alain Valdivia et autres
Abstract Functional precision medicine (FPM) offers a promising path forward in neuro-oncology, where genomic profiling alone often fails to predict therapeutic response. To bridge this gap, we developed the Screening Live Cancer Explants (SLiCE) platform, a rapid ex vivo drug screening assay …
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(code pays fourni par la source)