Gregory T. Armstrong

RADIATION ONCOLOGY WORKFLOW-INTEGRATED INDIVIDUALIZED RISK CALCULATOR TO COMPREHENSIVELY PREDICT FUTURE CARDIAC DISEASE RISK AMONG PEDIATRIC AND ADOLESCENT CANCER PATIENTS

Rebecca Howell, Qi Liu, Taylor Meyers, Arnold C. Paulino et autres

kidney injury following PBT may predispose to late radiation nephropathy, highlighting the need for early biomarkers and mitigation strategies in PBT patients.

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Long‐term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970–1999: A report from the Childhood Cancer Survivor Study

Duncan C. Ramsey, David Stephen Shulman, Grace C. Zhou, D D Cameron et autres

BACKGROUND: Survivors of Ewing sarcoma (EWS) are at significant long-term risk of treatment- and disease-related complications. The purpose of this study was to characterize long-term outcomes in EWS survivors according to treatment regimen. METHODS: Five-year survivors of EWS diagnosed between 1970 and …

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Abstract 867: Cancer treatment-related cardiotoxicity among survivors of childhood cancer: A comparative and integrated view of multiple measures of biological age acceleration.

Xiaoxi Meng, Tiffany Y. Eulalio, Kwangyeon Oh, Noel‐Marie Plonski et autres

Abstract Introduction: Mounting evidence suggests that childhood cancer survivors experience biological age acceleration (BioAgeAccel) and are at increased risk for cardiovascular disease. We performed an integrated analysis of multiple BioAgeAccel measures to examine how aging relates to treatment-related toxicity and cardiovascular risk, …

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Abstract 7889: Integrating genetic predictors into breast cancer risk stratification among female survivors of childhood cancer

Aparna Srinivasan, Jian Wang, Gavriel Y. Matt, Lauren J. Mills et autres

Abstract Background: Childhood cancer survivors are at high risk for developing breast cancer (BC). Existing BC risk stratification tools primarily consider childhood cancer treatment risk factors, but do not assess genetic predictors. The St. Jude Survivorship Portal (https://survivorship.stjude.cloud) is a new open-access …

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Abstract 3505: DNA methylation signatures of diet quality and treatment-related cardiotoxicity in childhood cancer survivors

Yoonji Kim, Xiaoxi Meng, Kwangyeon Oh, Tuo Lan et autres

Abstract Background: Childhood cancer survivors are at increased risk of cardiometabolic risk factors (CMRF) and cardiovascular disease (CVD) due to cancer treatment exposures. Whether DNA methylation (DNAm) signature of diet quality can remediate these risks remains unclear. Methods: We examined blood DNAm …

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Semen parameters in unirradiated, alkylating agent–exposed childhood cancer survivors in the St. Jude Lifetime Cohort Study

Daniel M. Green, Kendrick Li, Raymond W. Ke, Angela Delaney et autres

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Hypothalamic-pituitary deficiency after radiation in childhood cancer survivors is associated with rare variants in TNS2

Tomoko Yoshida, Fan Wang, Wonjong Moon, Sogol Mostoufi-Moab et autres

CONTEXT: Radiation to the hypothalamic-pituitary (HP) region (HP-RT) is a strong risk factor for HP deficiency among childhood cancer survivors (survivors). However, there is inter-individual variability in developing HP deficiency after similar HP-RT dose exposures. OBJECTIVES: To assess the genetic contribution to …

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Epigenome-wide analysis identifies DNA methylation mediators of treatment-related cardiometabolic risk in survivors of childhood cancer

Tiffany Y. Eulalio, Yoonji Kim, Xiaoxi Meng, Noel‐Marie Plonski et autres

Childhood cancer survivors face increased cardiometabolic risks from cancer treatment exposures, yet mechanisms remain unclear. Here, epigenome-wide analysis identifies 1893 DNA methylation (DNAm) sites in peripheral-blood-mononuclear-cells (PBMCs) associated with at least one cardiometabolic risk factor (CMRF), including obesity (n = 1720), abnormal …

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