A targetable dependency on nonsense-mediated decay for proteostasis and immune control in small cell lung cancer
Lucia A. Torres Fernández, Volker Boehm, Joel Kaufmann, Agnieszka Rumińska et autres
Summary Small cell lung cancer (SCLC) is among the deadliest cancers with excessive somatic alterations, expectedly resulting in immunogenic epitopes. However, patient benefit from immunotherapy is limited. We found abundant frameshift mutations in SCLC, regarded as highly immunogenic, counterbalanced by a hyperactive …
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bioRxiv (Cold Spring Harbor Laboratory)