REGN5381, an agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone in preclinical and clinical studies, and preserves renal function in models of Chronic Kidney Disease
Kishor Devalaraja-Narashimha, Aaron Kithcart, Michael Dunn, Jee Hae Kim et autres
Heart failure, Hypertension and Chronic Kidney Disease remain major contributors to morbidity and mortality, and often overlap within individuals. Novel approaches to modulate vascular tone and renovascular homeostasis may address unmet medical need in all three conditions. Natriuretic peptides signal through natriuretic …
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