Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity
Hongbin Zhuang, Xueshan Cao, X. Tang, Zhiyuan Liang et autres
DDX3X, a DEAD-box RNA helicase, has been identified as a risk gene for autism spectrum disorder (ASD). To elucidate the role of DDX3X mutations in ASD pathogenesis, HT22 cell models and mouse models with Ddx3x knockdown specifically in the medial prefrontal cortex …
cn (code pays fourni par la source)
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Translational Psychiatry