Giant cell tumor of bone inhibits osteoblastogenesis via WNT5B
Masaki Shimada, Tomonori Tsuyama, Naoto Yoshimura, Makoto Tateyama et autres
INTRODUCTION: Giant cell tumor of bone (GCTB) induces overproduction of bone-resorbing osteoclasts through receptor activator of nuclear factor kappa B ligand (RANKL), leading to bone resorption and destruction. Consequently, denosumab, a neutralizing antibody against RANKL (a cytokine essential for osteoclast induction), is …
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Journal of Bone and Mineral Metabolism